Gigantism And Acromegaly

Gigantism and acromegaly are syndromes caused by excessive secretion of GH (Hypersomatotropismus). These are almost always caused by an adenoma pituitary. Before epiphyseal closure occurs gigantism. Later, results in a acromegaly, which causes typical changes in the face and elsewhere. The diagnosis is made clinically and radiographs of the hands and the skull. The treatment consists in the destruction or at the distance of the triggering adenoma.

Many growth hormone (GH) -sezernierende adenomas contain a mutated form of the Gs protein, which is a stimulating protein for the adenylate cyclase. Cells with the mutated form of the Gs protein secrete GH even in the absence of growth-hormone-releasing hormone (GHRH). Few cases of ectopic GHRH-producing tumors, especially in pancreatic and lung have also been described.

Gigantism and acromegaly are syndromes caused by excessive secretion of GH (Hypersomatotropismus). These are almost always caused by an adenoma pituitary. Before epiphyseal closure occurs gigantism. Later, results in a acromegaly, which causes typical changes in the face and elsewhere. The diagnosis is made clinically and radiographs of the hands and the skull. The treatment consists in the destruction or at the distance of the triggering adenoma. Many growth hormone (GH) -sezernierende adenomas contain a mutated form of the Gs protein, which is a stimulating protein for the adenylate cyclase. Cells with the mutated form of the Gs protein secrete GH even in the absence of growth-hormone-releasing hormone (GHRH). Few cases of ectopic GHRH-producing tumors, especially in pancreatic and lung have also been described. Symptoms and complaints Pituitary gigantism This rare disease occurs when the GH hypersecretion begins in childhood before epiphyseal closure. The growth rate of the skeleton and the total size is increased, but small bone deformities occur. However, a soft tissue swelling occurs, and the peripheral nerves are enlarged. A delayed onset of puberty or hypogonadotropic hypogonadism are often present and result in a eunuchenhaften Habitus.Akromegalie In acromegaly, GH hypersecretion usually starts between 20 and 40 years. If GH secretion after epiphyseal closure occurs, the first symptoms are a coarsening of facial features and a soft tissue swelling in hands and feet. The overall appearance is changing, and larger rings, gloves and shoes are required. Photographs of the patient are important to document the course of the disease. Acromegaly © Springer Science + Business Media var model = {thumbnailUrl: ‘/-/media/manual/professional/images/574-acromegaly-s168-springer-high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ ? – / media / manual / professional / images / 574-acromegaly-S168-springer-high_de.jpg lang = en & thn = 0 ‘, title:’ acromegaly ‘description:’ u003Ca id = “v37895467 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDiese figure shows a patient with frontal bossing

Health Life Media Team

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