Gastrointestinal Stromal

These tumors grow slowly and their malignant potential varies from minimal to significant. Most (60-70%) occur in the stomach, 20-25% in the small intestine and a small number in the esophagus, colon and rectum. The average age at diagnosis is 50-60 years.

Gastrointestinal stromal are resulting from the mesenchymal precursor cells of the gastrointestinal wall gastrointestinal tumors. They are a mutation of a growth factor receptor gene (growth factor receptor gene), C-KIT, due. Some are caused by previous radiation therapy to the abdomen for other tumors. These tumors grow slowly and their malignant potential varies from minimal to significant. Most (60-70%) occur in the stomach, 20-25% in the small intestine and a small number in the esophagus, colon and rectum. The average age at diagnosis is 50-60 years. The symptoms vary with the location, but they include bleeding, dyspepsia and obstruction. The diagnosis is usually endoscopy, with biopsy and endoscopic ultrasound for staging. Treatment includes appendectomy. The role of radiotherapy and chemotherapy is unclear, but the tyrosine kinase inhibitor imatinib showed beneficial (n. D. Übers .: imatinib achieved in up to 80% of patients progressed prevention and the 2-year survival rate for patients with stable tumor disease up to 90%. Other new tyrosine kinase inhibitors show encouraging study data.)

Health Life Media Team

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