Formation Of Red Blood Cells

Erythrocytes survive approximately 120 days. Thereafter, they lose their cell membrane and by phagocytic cells in spleen, liver and bone marrow, in which the hemoglobin is released, removed from the circulation. In phagocytes and in hepatocytes the Hämoxygenasesystem for storage and subsequent recycling of iron provides. The heme is released through a series of enzymatic steps to bilirubin, and protein components are recycled. To maintain the red blood cell count due to their life about 1/120 erythrocytes are replaced daily. Immature red blood cells (reticulocytes) are continuously released and make up about 0.5-1.5% of peripheral erythrocyte population from.

The formation of red blood cells is called erythropoiesis in the bone marrow and is under the influence of the hormone erythropoietin (EPO) instead. As a result of decreased O2 offer (such as anemia or hypoxia) the juxtaglomerular cells of the kidney erythropoietin and increased levels of androgens produce. Except erythropoietin an adequate supply of basic components, mainly iron, vitamin B12 and folic acid for the production of erythrocytes necessary (For details on vitamin B12 and folic acid s. Vitamin deficiency, dependence and intoxication and iron s. Iron and iron deficiency anemia). The heme biosynthesis is discussed in overview of porphyria. Erythrocytes survive approximately 120 days. Thereafter, they lose their cell membrane and by phagocytic cells in spleen, liver and bone marrow, in which the hemoglobin is released, removed from the circulation. In phagocytes and in hepatocytes the Hämoxygenasesystem for storage and subsequent recycling of iron provides. The heme is released through a series of enzymatic steps to bilirubin, and protein components are recycled. To maintain the red blood cell count due to their life about 1/120 erythrocytes are replaced daily. Immature red blood cells (reticulocytes) are continuously released and make up about 0.5-1.5% of peripheral erythrocyte population from. Low androgen levels are associated in women and girls and in elderly patients with decreased EPO production and the formation of anemia may also favor such as the decrease in capacity of the bone marrow to produce red blood cells. At the age hemoglobin and hematocrit decrease slightly, but not drop below normal levels. In women, other factors lead (eg., Blood loss during menstruation or increased iron requirement through multiple pregnancies) often decreased erythrocyte values.

Health Life Media Team

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