Formation And Function Of Eosinophien

Eosinophilic granules contain the “major basic protein” and the eosinophil cationic protein, are toxic to various parasites, and mammalian cells. These proteins bind heparin and neutralize its anticoagulant activity. Eosinophil-derived neurotoxin myelinated neurons can severely damage. Eosinophil peroxidase, which differs significantly from the other peroxidases granulocytes, forms in the presence of hydrogen halides and oxidizing radicals. Charcot-Leyden crystals consist primarily of phospholipase B together and be in diseases in which eosinophilia is (eg., Asthma, eosinophilic pneumonia), detected in sputum, tissue and stool.

Eosinophilic granulocytes are derived from the same precursor cells such as monocytes / macrophages, neutrophils and basophils. They are a part of the innate immune system (overview of the immune system: Innate Immunity). Eosinophils have a variety of functions, but are especially important for the defense against parasitic infections. However, there is no direct evidence that eosinophils kill parasites in vivo, but they are toxic in vitro against helminths and worm infections usually are accompanied by eosinophilia. Although eosinophils are phagocytic active, they are in killing intracellular bacteria less effective than neutrophils. Eosinophils can modulate hypersensitivity reactions of immediate type by (which can cause vasoconstriction and bronchoconstriction) released by mast cell mediators such as histamine, leukotrienes, degrade or disable lysophospholipids and heparin. A prolonged eosinophilia can cause tissue damage, the mechanisms are not fully understood. Eosinophilic granules contain the “major basic protein” and the eosinophil cationic protein, are toxic to various parasites, and mammalian cells. These proteins bind heparin and neutralize its anticoagulant activity. Eosinophil-derived neurotoxin myelinated neurons can severely damage. Eosinophil peroxidase, which differs significantly from the other peroxidases granulocytes, forms in the presence of hydrogen halides and oxidizing radicals. Charcot-Leyden crystals consist primarily of phospholipase B together and be in diseases in which eosinophilia is (eg., Asthma, eosinophilic pneumonia), detected in sputum, tissue and stool. The normal peripheral blood eosinophil count varies; but it is generally believed that a number of 500 / ul is increased. Peripheral eosinophilia is characterized as weak: 500-1500 / ul Moderate: 1500-5000 / ul gravity:> 5000 / ul The diurnal level fluctuates and is inversely related to the Plasmakortisolspiegeln; The summit occurs at night, the nadir in the morning. The eosinophil count is under stress, while taking ?-blockers or corticosteroids and remove occasionally during bacterial or viral infections. The number may in allergic diseases, during certain (typically parasitic) infections and as a result many other reasons increase (eosinophilia). The half-life of eosinophils in the circulation is 6-12 h, with the most eosinophils found in the tissues (eg. B. upper respiratory and gastrointestinal tract, skin, uterus). The formation of eosinophils seems to be regulated by T cells, by secretion of hematopoietic growth factors granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 3 (IL-3) and interleukin 5 (IL-5). While GM-CSF and IL-3 stimulate the formation of other myeloid cells, IL-5 increases the exclusive formation of eosinophils.

Health Life Media Team

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