Fibrillar And Immunotaktoide Glomerulopathies

Histopathologically the fibrillar and immunotaktoide glomerulonephritis through organized deposition of nichtamyeloiden, microfibrillar or microtubular structures in the renal mesangium and basement membrane are identified.

Some experts believe that fibrillar and immunotaktoide Glomerulopathies are associated disorders. They are found in 0.6% of renal biopsies, come in men and women alike before and ? 10 years have been described in patients. The average age at diagnosis is about 45 years. The pathogenesis is unknown, although the deposition of immunoglobulin, in particular IgG-kappa and -Lambda light chains and complement (C3), a malfunction of the immune system suggests. In the patients accompanying carcinomas, Paraproteinemias, Kryglobulinämien, plasma cell, hepatitis C infection or SLE may occur, or they have a primary renal disease without evidence of systemic disease.

Histopathologically the fibrillar and immunotaktoide glomerulonephritis through organized deposition of nichtamyeloiden, microfibrillar or microtubular structures in the renal mesangium and basement membrane are identified. Some experts believe that fibrillar and immunotaktoide Glomerulopathies are associated disorders. They are found in 0.6% of renal biopsies, come in men and women alike before and ? 10 years have been described in patients. The average age at diagnosis is about 45 years. The pathogenesis is unknown, although the deposition of immunoglobulin, in particular IgG-kappa and -Lambda light chains and complement (C3), a malfunction of the immune system suggests. In the patients accompanying carcinomas, Paraproteinemias, Kryglobulinämien, plasma cell, hepatitis C infection or SLE may occur, or they have a primary renal disease without evidence of systemic disease. All patients have proteinuria, of which> 60% in the nephrotic range. In 60% of a microscopic hematuria and in approximately 70% of hypertension is present. About> 50% of patients have renal failure already in the initial diagnosis. Diagnostic renal biopsy The diagnosis results from the laboratory data and is confirmed by renal biopsy. When a nephrotic syndrome is present, investigations are carried out as in other cases of nephrotic syndrome. Urinalysis usually shows characteristic of nephritic syndrome and nephrotic syndrome ? ?. Serum C3 and C4 are usually measured and are occasionally reduced. Light microscopic examination of a biopsy sample shows a mesangial expansion by amorphous eosinophilic deposits and a slight mesangial cell cluster. Various other changes may be present (eg. As crescent formation, membranoproliferative pattern) in the light microscope. The Congo red staining on amyloid is negative. Immunostaining shows IgG and C3 and sometimes kappa and lambda light chains in the region of the deposits. Under the electron microscope glomerular deposits of extracellular elongated, unbranched or microfibrils microtubules are visible. In fibrillar glomerulonephritis, the diameter of the microfibrils and microtubules varies from 20 to 30 nm. In immunotaktoider glomerulonephritis, the diameter of the microfibrils and microtubules varies from 30 to 50 nm. In contrast, the fibrils in amyloidosis 8 to 12 nm. Due to the presence of microtubular (as opposed to smaller microfibrillar) structures in the deposits some experts distinguish the immunotaktoide of the fibrillar glomerulonephritis; Another distinction between the two forms by means of a corresponding systemic disease. For example, indicate a immunotaktoide glomerulonephritis a lymphoproliferative disorder, monoclonal gammopathy, cryoglobulinemia or SLE. Fibrillar glomerulopathy (Mesangial proliferation) Figure provided by Agnes Fogo, M.D., and the American Journal of Kidney Disease, Atlas of Renal Pathology (see www.ajkd.org). var model = {thumbnailUrl: ‘/-/media/manual/professional/images/fibrillary_glomerulopathy_mesangial_proliferation_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/fibrillary_glomerulopathy_mesangial_proliferation_high_de.jpg?la = en & thn = 0 ‘, title:’ fibrillary glomerulopathy (Mesangial proliferation) ‘description:’ u003Ca id = “v38396943 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “” para “” u003e u003cp u003eEine mesangial proliferation indicates a fibrillar glomerulopathy; However

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