Ependymomas

Ependymomas are slow growing tumors of the central nervous system affecting the ventricular system. Diagnosis is based on liver biopsy. The therapy is a combination of surgical resection, radiotherapy and chemotherapy.

Ependymomas are the third most common CNS tumors in children (after astrocytomas and medulloblastomas) and make 10% of the pediatric brain tumors. The mean age at diagnosis is six years, but <3 years can be found ependymomas in children.

Ependymomas are slow growing tumors of the central nervous system affecting the ventricular system. Diagnosis is based on liver biopsy. The therapy is a combination of surgical resection, radiotherapy and chemotherapy. Ependymomas are the third most common CNS tumors in children (after astrocytomas and medulloblastomas) and make 10% of the pediatric brain tumors. The mean age at diagnosis is six years, but <3 years can be found ependymomas in children. Ependymomas arise from the ependymal lining of the ventricular system. Up to 70% of ependymomas occur in the posterior cranial fossa, both Grade II and Grade I tumors in the posterior cranial fossa tend to spread locally to the brain stem. Symptoms and complaints Many symptoms are caused by increased intracranial pressure. Infants may be presented with developmental delay and irritability. Changes in mood, personality or the concentration may occur. Convulsions, loss of balance and gait disorders, or symptoms of spinal cord compression (eg. As back pain, incontinence of bladder and bowel control) are possible. Diagnosis MRI Histological examination of biopsy samples or the entire resected tumor The diagnosis of ependymoma based on MRI. The final diagnosis is made by using tumor tissue from a biopsy or in the ideal case by Gesamtresektion of the tumor at the first presentation. Forecast survival depends on age, and how much of the tumor can be removed: Complete or almost complete removal of 51 to 80% survival less than 90% distance: 0 to 26% survival Children who survive are at risk of neurological deficits to develop. Therapy Surgical resection, usually followed by radiation therapy Occasionally chemotherapy Surgical resection is critical, and the degree of resection is one of the most important prognostic factors. By radiation therapy survival has increased and they should be given after surgery; However, a small subset of ependymomas can potentially be cured only by surgery. It has not clearly confirmed that chemotherapy improves survival, but it can be used in some children to shrink the tumor before Gesamtresektion or a second operation.

Health Life Media Team

Leave a Reply