Eosinophilia

Eosinophilia is defined as a Eosinophilenkonzentration> 500 / ul in the peripheral blood. The causes and associated disorders for this are numerous, but often have allergic reactions or parasitic infections before. The diagnosis includes selective investigations depending on the clinically suspected causes. The treatment depends on the particular cause.

Eosinophilia has features of an immune response: An agent as Trichinella spiralis triggers a primary response with relatively low Eosinophilenwerten out, whereas repeated exposures result in a reinforced or secondary eosinophilic response. Various released from mast cells and basophils substances induce IgE-mediated production of eosinophils. These include eosinophil chemotactic factor of anaphylaxis, leukotriene B4, complement complex (C5 / C6 / C7) and histamine (over a narrow concentration range).

Eosinophilia is defined as a Eosinophilenkonzentration> 500 / ul in the peripheral blood. The causes and associated disorders for this are numerous, but often have allergic reactions or parasitic infections before. The diagnosis includes selective investigations depending on the clinically suspected causes. The treatment depends on the particular cause. Eosinophilia has features of an immune response: An agent as Trichinella spiralis triggers a primary response with relatively low Eosinophilenwerten out, whereas repeated exposures result in a reinforced or secondary eosinophilic response. Various released from mast cells and basophils substances induce IgE-mediated production of eosinophils. These include eosinophil chemotactic factor of anaphylaxis, leukotriene B4, complement complex (C5 / C6 / C7) and histamine (over a narrow concentration range). The slight eosinophilia itself is asymptomatic, but levels can cause ? 1500 / ul organ damage. Although any organ can be involved, heart, lungs, spleen, skin and nervous system are typically affected. Organ damage typically occur due to tissue inflammation and response to cytokines and chemokines that are released from the eosinophils, as well as on immune cells that are recruited to the tissue on. Sometimes, patients with a very severe eosinophilia (z. B. Eosinophilenkonzentration of> 100,000 / ul), which usually have a eosinophil leukemia, complications of hyperleukocytosis develop (hypereosinophilic syndrome). Eosinophilia (Peripheral blood smear) © Springer Science + Business Media var model = {thumbnailUrl: ‘/-/media/manual/professional/images/535-eosinophilia-peripheral-blood-smear-s129-springer-arrows-high_de.jpg?la = en & thn = 0 & mw = 350 ‘, imageUrl:’ /-/media/manual/professional/images/535-eosinophilia-peripheral-blood-smear-s129-springer-arrows-high_de.jpg?la=de&thn=0 ‘, title : ‘eosinophilia (Peripheral blood smear)’, description: ‘ u003Ca id = “v38395983 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDieses picture shows eosinophilic cells (arrow) u003c / p u003e u003c / div u003e. ‘credits’ © Springer Science + Business Media’

Health Life Media Team

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