Drug Eruptions And Reactions

Drugs can trigger numerous Hautexantheme and reactions. The most serious of which are discussed elsewhere in the MSD Manual. These include Stevens-Johnson syndrome and toxic epidermal necrolysis, the hypersensitivity syndrome, serum sickness, which exfoliative dermatitis, angioedema and anaphylaxis, as well as drug-related vasculitis. In addition to hair loss drug, lichen planus, erythema nodosum, pigmentation disorders, SLE, photosensitivity reactions, pemphigus and pemphigoid can cause. Other drug reactions are due to the distinction of lesion (types of drug reactions and typical pathogens). Symptoms and discomfort symptoms and complaints vary depending on the cause and the specific reaction (types of drug reactions and typical pathogens). Types of drug reactions and typical pathogens type of reaction description and comments Typical pathogens Acneiform eruptions resembling acne, but lack of blackheads and usually sudden occurrence corticosteroids, iodides, bromides, hydantoins, androgenic steroids, lithium, isoniazid, phenytoin, phenobarbital, vitamins B2, B6 and B12 acrocyanosis appears as gray-blue coloration of the tips of fingers, toes, nose and ears bleomycin Acute generalized exanthematous pustulosis Quick occurring and propagating pustular eruption Aminopenicillins (ampicillin, amoxicillin and bacampicillin), calcium channel blockers, cephalosporins, tetracyclines bursts of blistering kick with widespread sores and blisters on the bullous autoimmune diseases similar (bullous diseases) penicillamine and other thiol-containing medications (eg. As ACE inhibitors, gold sodium thiomalate) Cutaneous necrosis Appears as defined, painful, red or hemorrhagic lesions that progress to hemorrhagic bubbles and full-thickness skin necrosis with scabbing warfarin, heparin, barbiturates, epinephrine, norepinephrine, vasopressin, levamisole ( pollutant unprofessional produced cocaine) drug-induced lupus Appears as a lupus-like syndrome, but often without the rash hydrochlorothiazide, minocycline hydralazine, procainamide, anti-TNF agents substance reaction with eosinophilia and systemic symptoms or substance hypersensitivity syndrome Manifested as fever, facial edema and rash 2-6 weeks after the first dose of a drug patients increased eosinophils, atypical lymphocytes, hepatitis, pneumonitis, lymphadenopathy and myocarditis have anticonvulsants, allopurinol, sulfonamides erythema nodosum Characterized by tender red nodules, mostly in the pretibial region, but occasionally arms, or other areas on sulfonamides, oral contraceptives Exfoliative dermatitis characterized by redness and scaling of the entire skin surface (Exfoliative Dermat itis) May be fatal penicillin, sulfonamides, hydantoins Solid drug eruptions show as frequently isolated, well-circumscribed, circular or egg-shaped, dark red or purple lesions on the skin or mucous membranes (in particular the genitals) and immerse each time the drug is taken , in the same locations on tetracyclines, sulfonamides, NSAIDs Lichenoid or lichen planus-like lesions appearing as rectangular papules that coalesce to form scaly plaques (lichen planus) anti-malarial drugs, chlorpromazine, thiazides Morbilliform or maculopapular lesions (eruptions) rich in the appearance of a morbilliform disease up to rash of pityriasis rosea is similar vulnerabilities itchy, typically occur 3-7 days after the onset of drug taking on almost any drug (especially barbiturates, analgesics, sulfonamides, ampicillin and other antibiotics) mucocutaneous eruptions rich little from a few blisters or urticaria-like skin lesions up to painful ulcers with widespread bullous skin lesions (erythema multiforme and Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)) penicillin, barbiturates, sulfonamides ( including derivatives to Behandlun g are used by high blood pressure and diabetes) deflections due to photosensitivity appearing as areas of dermatitis or gray-blue hyperpigmentation (phenothiazines and minocycline) on the skin, which is exposed to the sun or other sources of ultraviolet light phenothiazines, tetracyclines, sulfonamides, chlorothiazide, artificial sweeteners occur purpura rashes appear as a non-bleach hemorrhagic skin spots, which vary in size Most common in the lower extremities, but can be anywhere, and a more serious purpura vasculitis can view II as a type of cytotoxic reactions type IV cell mediated delayed allergic reactions or type III h umorale allergic immune complex vasculitis occur chlorothiazide, meprobamate, anticoagulants serum sickness-like drug reaction a type III immune complex reaction Acute urticaria and angioedema often than morbilliform or scarlatiniforme rashes may polyarthritis, myalgia, Polysynovitis, fever and neuritis penicillin, insulin, alien proteins Stevens-Johnson syndrome characterized by focal areas of skin necrosis and infection of the mucous membranes (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)) lips develop hemorrhagic crusts and ulcerations overlap with toxic Population- rmaler necrolysis anticonvulsants, NSAIDs, penicillin, sulfonamides Nekrolysis necrolysis Characterized by large areas relaxed, easy-peelable epidermis, which gives the skin a verbrühtes appearance (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)) May at 30- 40% of patients be fatal similar to staphylococcal scalded skin syndrome (staphylococcal scalded skin syndrome), a similar disease that occurs overlap with Stevens-Johnson syndrome anticonvulsants, barbiturates, hydantoins, penicillin, sulfonamides urticaria Together Klassischerwe in infants, young children and immunocompromised patients ise, but not always IgE mediated via typical well-defined edematous wheals easily recognizable sometimes the first indication of an impending serum sickness, in which develop fever, joint pain and other systemic symptoms within days. Penicillin, aspirin, sulfa drugs, ACE inhibitors acne-like rash DR P. arazzi / SCIENCE PHOTO LIBRARY var model = {thumbnailUrl: ‘/ – / media / manual / professional / images / c0263335-acneiform rash–science-photo-library-high_de ? lang = en & .jpg thn = 0 & mw = 350 ‘, imageUrl:’ /-/media/manual/professional/images/c0263335-acneiform-rash-science-photo-library-high_de.jpg?la=de&thn=0 ‘, title ‘acne-like rash’, description: ‘ u003Ca id = “v37894800 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDieses Fo to shows acne-like rash on the chest

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