Down Syndrome (Trisomy 21)

(Down syndrome, trisomy E)

Down’s syndrome is an abnormality of chromosome 21, which can cause short stature and characteristic appearance mental retardation, microcephaly. The diagnosis is suspected based on clinical examination and abnormal development and confirmed by cytogenetic analysis. Treatment depends on the specific findings and abnormalities.

The overall incidence of live births is about 1 out of 700, but the risk increases with maternal age. If the mother is 20 years old, the risk is 1 in 2000 births, with 35 years, it is one of 365, and 40 years is 1 in 100. However, since most births occur in younger women, are the majority of children with down syndrome women <35 years. Only about 20% of children with Down syndrome are born to mothers> 35 years.

Down’s syndrome is an abnormality of chromosome 21, which can cause short stature and characteristic appearance mental retardation, microcephaly. The diagnosis is suspected based on clinical examination and abnormal development and confirmed by cytogenetic analysis. Treatment depends on the specific findings and abnormalities. The overall incidence of live births is about 1 out of 700, but the risk increases with maternal age. If the mother is 20 years old, the risk is 1 in 2000 births, with 35 years, it is one of 365, and 40 years is 1 in 100. However, since most births occur in younger women, are the majority of children with down syndrome women <35 years. Only about 20% of children with Down syndrome are born to mothers> 35 years. Etiology in 95% of cases there is an extra whole chromosome 21 (trisomy 21), which mostly comes from the maternal side. Such people have 47 chromosomes. Down syndrome karyotype (Female) Biophoto Associates / SCIENCE PHOTO LIBRARY var model = {thumbnailUrl: ‘/-/media/manual/professional/images/c0219838_female_karyotype_showing_downs_syndrome_science_photo_library_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / ? media / manual / professional / images / c0219838_female_karyotype_showing_downs_syndrome_science_photo_library_high_de.jpg lang = en & thn = 0 ‘, title:’ down syndrome karyotype (Female) ‘description:’ u003Ca id = “v37897501 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDas down syndrome is characterized by an extra copy of genetic material on the 21st chromosome. u003c / p u003e u003c / div u003e ‘credits’ Biophoto Associates / SCIENCE PHOTO LIBRARY’

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