Desquamative Interstitial Pneumonia

The desquamative interstitial pneumonia is a chronic inflammation of the lung that is characterized by a mononuclear infiltrate the air spaces. It occurs almost exclusively in former or current smokers.

The desquamative interstitial pneumonia is a type of idiopathic interstitial pneumonia. The vast majority of adult patients with desquamative interstitial pneumonia are smokers who develop the disease primarily in the third or fourth decade of life.

The desquamative interstitial pneumonia is a chronic inflammation of the lung that is characterized by a mononuclear infiltrate the air spaces. It occurs almost exclusively in former or current smokers. The desquamative interstitial pneumonia is a type of idiopathic interstitial pneumonia. The vast majority of adult patients with desquamative interstitial pneumonia are smokers who develop the disease primarily in the third or fourth decade of life. The lung parenchyma is often equally attacked. The alveolar walls are lined with clumsy cubic pneumocytes into the alveolar walls is a moderate infiltrate of lymphocytes, plasma cells and occasional eosinophils to find. The fibrosis of the alveolar walls is at worst only slightly. The most striking feature is the presence of numerous pigmented macrophages in the distal airspaces that are held in the first description mistakenly sloughed pneumocytes. A honeycomb lung is rare. Similar, but less pronounced findings come in respiratory bronchiolitis interstitial lung disease before (R picture), suggesting that the desquamative interstitial pneumonia and R picture are different manifestations of the same diseases caused by cigarette smoking. Diagnosis High-resolution CT (HRCT) Sometimes surgical lung biopsy in the chest x-ray can show both sides basal blurry haze without honeycombing, but this is up to 20% of cases is normal. HRCT shows multifocal or diffuse, basal, subpleural ground glass opacities. Cysts can be present, often in areas of ground glass opacities. Irregular linear and reticular opacities are common, but usually not the dominant features. A honeycomb formation may be visible, occurs in a minority of patients and is usually limited. Sometimes a surgical lung biopsy is necessary. Smoking cessation therapy Sometimes corticosteroids or cytostatics smoking cessation leads to clinical improvement at an estimated 75% of patients. Patients in whom no improvement sets could respond to corticosteroids or cytotoxic drugs. The prognosis is good with a 10-year survival rate of approximately 70%.

Health Life Media Team

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