Decreased Erythropoiesis

Microcytic anemia caused by an inadequate or impaired heme or globin synthesis. Among the microcytic anemia iron deficiency anemia, iron transport defects, iron utilization disorders include (including some sideroblastärer anemia and lead poisoning) and thalassemia (which also cause hemolysis; thalassemia). Patients with microcytic anemia usually require a study of iron stores (iron deficiency anemia).

When anemia is defined as the reduction in red blood cell count, hemoglobin and hematocrit. You can by decreased red blood cell production (erythropoiesis), increased erythrocyte loss or blood loss be caused. Anemia due to decreased erythropoiesis are characterized by a reticulocytopenia, which usually already in the peripheral blood smear is visible (laboratory tests). The red cell indices, especially the MCV, restrict the differential diagnosis of diminished erythropoiesis and thereby determine what further studies are needed. Microcytic anemia caused by an inadequate or impaired heme or globin synthesis. Among the microcytic anemia iron deficiency anemia, iron transport defects, iron utilization disorders include (including some sideroblastärer anemia and lead poisoning) and thalassemia (which also cause hemolysis; thalassemia). Patients with microcytic anemia usually require a study of iron stores (iron deficiency anemia). Normocytic anemia caused by a primary bone marrow insufficiency. They are generally characterized by a normal red blood cell distribution width (RDW) and normochromic indices. They are by Hypo proliferation, eg. As characterized by a lack of erythropoietin (EPO), or inadequate response to EPO, hypoplasia (in aplastic anemia), Myelophthise or myelodysplasia. Macrocytic anemia is often impaired expression of a DNA synthesis and are formed, for. As by vitamin B12 or folate deficiency. Some anemias have different findings in the peripheral blood smear. Anemia in chronic diseases may be microcytic or normocytic. In anemia due to myelodysplastic syndromes can be found both microcytic and normocytic and macrocytic forms. The therapy of deficient erythrocytes production depends on its cause. In anemias due to renal failure, however, erythropoiesis can be stimulated with human recombinant erythropoietin. If the treatment aims to increase erythropoiesis, the additional administration of iron is useful.

Health Life Media Team

Leave a Reply