Daptomycin

Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to bacterial cell membranes and caused due to the potassium efflux and the associated destruction of DNA, RNA and protein synthesis rapid depolarization of the membrane which leads to a rapid concentration-dependent bacterial cell death (efficacy). Indications Daptomycin is active against the following: Gram-positive bacteria (broad spectrum) Multi-resistant Gram-positive bacteria (because cross-resistance with other classes of antibiotics does not occur) daptomycin is mainly use for infections caused by vancomycin and methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci pneumococci with reduced penicillin sensitivity However, methicillin-resistant S. aureus and vancomycin-resistant enterococci are resistant to daptomycin during therapy, resulting in relapsing or persistent infections. Daptomycin ceftriaxone is inferior to pneumonia, probably because daptomycin can bind to the lung, causing the efficacy of daptomycin is lreduziert in the alveolar epithelium fluid. Contraindications daptomycin is contraindicated in patients who have had an allergic reaction to it. Use during pregnancy and lactation daptomycin is in pregnancy category B (animal studies show no risk, human experience is incomplete). Daptomycin is excreted in breast milk, but its oral bioavailability is low; the effects on breastfeeding infants are unknown. Side effects Side effects include myopathy Eosinophilic pneumonia Chronic use can lead to reversible organizing pneumonia with eosinophilic pulmonary infiltrates, presumably because daptomycin binds to the lung and thus accumulates in the alveoli. Skeletal myopathy due to daptomycin is reversible, but dosage is rare for a once / day on considerations for dosing daptomycin is given once daily parenterally. The serum protein binding is> 90%. In renal insufficiency, the dosage should be adjusted. Because daptomycin reversible myopathy skeletal muscle can cause, patients should be monitored with respect to muscle pain or weakness and serum creatine kinase (CPK) should be monitored weekly.

Health Life Media Team

Leave a Reply