Cyclosporiasis And Cystoisosporiasis

Cyclosporiasis is an infection with Cyclospora cayetanensis; Cystoisosporiasis is an infection with Cystoisospora (Isospora) belli. Both organisms are among the Kokzidienprotozoen. The symptoms consist mainly of an aqueous diarrhea with gastrointestinal and systemic complaints. The diagnosis is made by the detection of characteristic oocysts in stool or intestinal biopsy samples. Treatment is usually with trimethoprim / sulfamethoxazole.

The life cycles of C. cayetanensis and C. belli similar to those of Cryptosporidium, except that oocysts must sporulate to become infectious. The human Cyclosporiasis and Cystoisosporiasis occur in tropical and subtropical climates most often. The pathogen is transmitted fecal-oral route via contaminated food or drinks. In the 1990s, outbreaks of C. cayetanensis in North America were triggered by the consumption of imported raspberries, who came from Guatemala. In the summer of 2013, an outbreak in several states of the USA, which affected hundreds of people returned to the consumption of pre-washed salad mixes was.

Cyclosporiasis is an infection with Cyclospora cayetanensis; Cystoisosporiasis is an infection with Cystoisospora (Isospora) belli. Both organisms are among the Kokzidienprotozoen. The symptoms consist mainly of an aqueous diarrhea with gastrointestinal and systemic complaints. The diagnosis is made by the detection of characteristic oocysts in stool or intestinal biopsy samples. Treatment is usually with trimethoprim / sulfamethoxazole. The life cycles of C. cayetanensis and C. belli similar to those of Cryptosporidium, except that oocysts must sporulate to become infectious. The human Cyclosporiasis and Cystoisosporiasis occur in tropical and subtropical climates most often. The pathogen is transmitted fecal-oral route via contaminated food or drinks. In the 1990s, outbreaks of C. cayetanensis in North America were triggered by the consumption of imported raspberries, who came from Guatemala. In the summer of 2013, an outbreak in several states of the USA, which affected hundreds of people returned to the consumption of pre-washed salad mixes was. Symptoms and complaints The main symptom is an acute non-bloody, watery diarrhea with fever, abdominal cramps, nausea, anorexia, malaise and weight loss. In immunocompetent patients, the disease is usually self-limiting, but can last for weeks. For hosts with a decreased cell-mediated immunity such. As in AIDS can Cyclosporiasis and Cystoisosporiasis lead to severe and persistent diarrhea with bulky chairs, reminiscent of a cryptosporidiosis. An extra-intestinal disease may be associated in AIDS patients with cholecystitis and disseminated infection. Diagnosis Microscopic examination of stool Diagnosis is made by detection of oocysts on microscopic stool examination. Detection is facilitated if the fecal samples with the modified acid-fast staining or modified safranin staining are stained. Multiple (? 3) stool samples may be needed because the Zystesekretion may be intermittent. The diagnosis is sometimes only made after intracellular parasite stages were detected in biopsies intestinal tissue. In a Cystoisosporiasis the cysts appear autofluorescent during an ultraviolet microscopy. The chair may contain Charcot-Leyden crystals (hexagonal, double-pointed and often needle-like crystals) derived from eosinophils. Unlike other protozoal a Cystoisosporiasis can cause eosinophilia in peripheral blood. Therapy trimethoprim / sulfamethoxazole The treatment of choice for both Cyclosporiasis as well as Cystoisosporiasis consists of trimethoprim-sulfamethoxazole (TMP-SMX) in a double dosage, 160 mg TMP and SMX 800 mg p.o. 2 times daily for 7-10 days at Cyclosporiasis or 10 days at Cystoisosporiasis. Children receive 5 mg / kg TMP and 25 mg / kg SMX 2 times a day for the same number of days. In patients with AIDS, higher doses and longer duration may be needed and the treatment of acute infection is usually followed by a long-term suppressive therapy. The establishment or optimization of antiretroviral therapy (ART) is important. For Cyclosporiasis an alternative to TMP / SMX has yet to be identified. Ciprofloxacin 500 mg p.o. 2 times daily for 7 days was applied to Cystoisosporiasis, but it is less effective than TMP / SMX. Prevention is the same as cryptosporidiosis (cryptosporidiosis: Prevention).

Health Life Media Team

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