Cryptococcosis

(European blastomycosis; torulosis)

Cryptococcosis is a pulmonary or disseminated infection is acquired through inhalation of dust, which contains the yeast Cryptococcus neoformans bekapselte or C. gattii. The symptoms are those of pneumonia, meningitis or involvement of the skin, bones or viscera. The diagnosis is made clinically and microscopically and confirmed by the cultural detection of pathogens or “fixed-tissue staining”. The therapy, if necessary, is carried out with azoles, amphotericin B or flucytosine.

(See also the “Infectious Diseases Society of America Practice Guidelines for the Management of Cryptococcal Disease”.)

Cryptococcosis is a pulmonary or disseminated infection is acquired through inhalation of dust, which contains the yeast Cryptococcus neoformans bekapselte or C. gattii. The symptoms are those of pneumonia, meningitis or involvement of the skin, bones or viscera. The diagnosis is made clinically and microscopically and confirmed by the cultural detection of pathogens or “fixed-tissue staining”. The therapy, if necessary, is carried out with azoles, amphotericin B or flucytosine. (See also the “Infectious Diseases Society of America Practice Guidelines for the Management of Cryptococcal Disease”.) The spread of C. neoformans is the world; it is with bird droppings (especially pigeon) contaminated soils present. Cryptococcosis is one of the opportunistic AIDS-defining illness (usually with CD4 levels <100 / ul associated), although patients with Hodgkin's lymphoma, other lymphomas and sarcoidosis as well as patients who are undergoing long-term treatment with corticosteroids, also increased have risk; This also applies to recipients of solid organ transplants. C. gattii is primarily associated with trees, especially eucalyptus, and, unlike C. neoformans, not associated with birds and caused more in immunocompetent hosts a disease. In the Pacific Northwest and in Papua New Guinea and northern Australia there have been outbreaks. Pathophysiology cryptococcosis is acquired by inhalation and therefore usually affects primarily the lungs. Many patients have asymptomatic, self-limited primary lung lesions. In immunocompetent patients these isolated pulmonary lesions usually heal spontaneously without dissemination; even without antifungal therapy. After inhalation, is Cryptococcus can spread, often to the brain and meninges and typically manifested as microscopic multifocal intracerebral lesions. Meningeal granulomas and larger focal brain lesions may be present. Although pulmonary involvement is rarely dangerous, meningitis is life-threatening and requires aggressive treatment. There may be focal disseminations in skin terminations of the long bones, joints, liver, spleen, kidney, prostate, and other tissues. These lesions usually cause, except those of the skin, few or no symptoms. Rarely occurs pyelonephritis with a renal papillary necrosis. The tissues involved typically include cystic masses yeasts that appear gelatinous due to accumulated kryptokokkaler capsular polysaccharides, but acute inflammatory changes minimally or not exist. Symptoms and complaints manifestations depend on the affected area. CNS because the inflammatory response is not pronounced, there is usually only a slight fever and neck stiffness is rare. In patients with AIDS, a cryptococcal meningitis can cause minimal or no symptoms, but headaches are common; sometimes it comes too slowly progressive altered states of consciousness. Because most complaints at a cryptococcal meningitis attributable to the cerebral edema, they are usually non-specific (eg. As headaches, blurred vision, confusion, depression, agitation or other behavioral disorders). With the exception of ocular or facial paralysis focal symptoms occur only rarely and only relatively late in the course before. Because of cerebral edema can cause blindness or optic direct involvement of the tract. Cryptococcosis (central nervous system) Image courtesy of www.doctorfungus.com © 2005. var model = {thumbnailUrl: '/-/media/manual/professional/images/cryptococcosis_central_nervous_system_high_de.jpg?la=de&thn=0&mw=350' imageUrl: '/-/media/manual/professional/images/cryptococcosis_central_nervous_system_high_de.jpg?la=de&thn=0', title: 'cryptococcosis (central nervous system) ", description:' u003Ca id = " v38396406 ""class = "" anchor "" u003e u003c / a u003e u003cdiv class = "" para "" u003e u003cp u003eBei an immunocompromised host causes cryptococcal infection meningitis that manifest themselves in the imaging and large

Health Life Media Team

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