Crypto Genes Organizing Pneumonia

(Bronchiolitis obliterans organizing pneumonia)

The cryptogenic organizing pneumonia (COP) is an idiopathic disease, are filled in the alveolar ducts and alveoli with granulation tissue and chronic inflammation occurs in the adjacent alveoli.

COP, a form of idiopathic interstitial pneumonia affects men and women equally, usually between the ages of 40 and 60 years. Cigarette smoking appears to be a risk factor.

The cryptogenic organizing pneumonia (COP) is an idiopathic disease, are filled in the alveolar ducts and alveoli with granulation tissue and chronic inflammation occurs in the adjacent alveoli. COP, a form of idiopathic interstitial pneumonia affects men and women equally, usually between the ages of 40 and 60 years. Cigarette smoking appears to be a risk factor. About half of the patients reported an community acquired pneumonia-like symptoms (i. E., A cold-like persistent disorder that is characterized by cough, fever, malaise, fatigue and weight loss) at the time of the outbreak. Increasing cough and exertional guide the patient to the doctor normally. Examination of the thoracic shows a fine, dry, inspiratory crepitation (Sklerosiphonie). Diagnosis High-resolution CT (HRCT) Sometimes surgical lung biopsy Diagnosis requires imaging tests and a surgical lung biopsy if the diagnosis is not otherwise clear. The chest X-ray image shows both sides diffuse peripheral shadows of the alveoli with normal lung volumes. A peripheral distribution pattern similar to eosinophilic chronic pneumonia can occur. Rarely, the shading of the alveoli are one-sided. Occur frequently recurrent and wandering shadows. Rarely an irregular linear or nodular interstitial drawing or honeycombed changes are seen in the first presentation. HRCT of the lung shows a mottled consolidation of airspaces (at 90% of patients), frosted glass opacities, small nodular opacities as well as thickening and widening of the bronchial walls. The patchy opacities are frequently localized in the lung periphery, often in the lower lung fields. When HRCT significantly greater extent of the disease can be seen as suspects in the chest X-ray findings. The pulmonary function tests normally shows a restriction, in 21% of patients airflow obstruction (forced expiratory volume ratio of forced to forced vital capacity [FEV1 / FVC] <70%) and occasionally normal findings. The results of routine laboratory tests are nonspecific. In about half of patients leukocytosis occurs without increased eosinophil numbers. Initially, the BSG is often accelerated. In lung biopsies from extensive proliferation of granulation tissue shows in the small airways and alveolar passages with a chronic inflammatory response of the neighboring alveoli. Foci of organizing pneumonia are nonspecific and secondary to other pathological processes, including infections, vasculitis, lymphomas and other interstitial lung diseases such as idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, connective tissue-related interstitial lung disease, drug-induced pulmonary disease, hypersensitivity pneumonitis and eosinophilic pneumonia. Crypto genes organizing pneumonia Image courtesy of Talmadge E. King, M.D. var model = {thumbnailUrl: '/-/media/manual/professional/images/bronchiolitis_obliterans_organizing_pneumonia_high_de.jpg?la=de&thn=0&mw=350' imageUrl: '/-/media/manual/professional/images/bronchiolitis_obliterans_organizing_pneumonia_high_de.jpg?la = en & thn = 0 ', title:' crypto genes organizing pneumonia ', description:' u003Ca id = "v37893176 " class = ""anchor "" u003e u003c / a u003e u003cdiv class = ""para "" u003e u003cp u003eDas high resolution CT showing spotty consolidation of airspaces

Health Life Media Team

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