Components Of The Immune System

The immune system consists of cellular and molecular components that work together to destroy antigens. Antigen presenting cells, although some antigens can stimulate an immune response directly, require T cell-dependent immune responses typically acquired Ag-presenting cells (APC) to match originating from antigen peptides with molecules of the major histocompatibility complex (MHC). Intracellular Ag (. E.g. viruses) can be processed and every nucleated cell – all nucleated cells have class I MHC molecules on – are passed on CD8 + cytotoxic T cells. By encoding proteins that interact with this process, some viruses (eg. As cytomegalovirus) can evade elimination. However Extracellular antigen must be converted to peptide and tied with class II MHC surface molecules on professional APC in order to become of CD4 T-helper cells (TH) detected. The following cells constitutively express MHC class II molecules and thus act as a professional APC: B-cells, monocytes, macrophages, monocytes, dendritic cells in the circulation are precursors of macrophages located in the tissue. Monocytes migrate into tissues where they develop over about 8 hours, under the influence of macrophage colony stimulating factor (M-CSF), the different cell types (eg. As endothelial cells, fibroblasts) is delivered to macrophages. In infected areas give cytokines from activated T cells (eg., Interferon ? [IFN-?), which initiate the production of a macrophage Migrationsinhibitationsfaktors, thus preventing the migration of macrophages. Macrophages activated by IFN-? and granulocyte-macrophage colony-stimulating factor (GM-CSF). Activated macrophages destroy intracellular organisms and secrete IL-1 and tumor necrosis factor ? (TNF-?). These cytokines allow the secretion of IFN-? and GM-CSF and increase the expression of adhesion molecules on endothelial cells, which facilitates the influx of leukocytes and the destruction of pathogens. Based on various gene expression profiles of macrophage subtypes (eg. B. M1, M2) have been identified. Macrophage subtypes Plate (produced by TH2 cells cytokines) M1 M2 activation means stimulation of Toll-like receptors IFN-? (produced by TH1 cells cytokine) IL-4 and IL-13 Produced cytokines Pro-inflammatory cytokines (for. Example, TNF-? ) Immunosuppressive cytokines (eg., IL-10) Other functions beneficiaries TH1 responses are strongly mikrobi zid support the tissue remodeling IFN = interferon; IL = interleukin; TH1 cells = type 1 T-helper cells; TH2 cells = type 2 T-helper cells; TNF = tumor necrosis factor. Dendritic cells are found in the skin (as Langerhans cells), lymph nodes and throughout the body tissues. Dendritic cells in the skin act as Guardian APC by absorbing the antigen and then migrate to local lymph nodes where they can activate T cells. Follicular dendritic cells are a particular cell line because they do not express class II MHC molecules and therefore no antigen to TH presenting cells. You are not phagocytic and have receptors for the crystallizable fragment (Fc) region of IgG and the complement, allowing them to bind to immune complexes and present the complex of B-cell maturation in centers of secondary lymphoid organs. Overview of the B and T cell function var model = {videoId: ‘3905171402001’ playerId: ‘H1xmEWTatg_default’ imageUrl: ‘http://f1.media.brightcove.com/8/3850378299001/3850378299001_3905210739001_vs-5470e3b3e4b0de73aed12ec5- ? 767904719001.jpg pubId = 3850378299001 & videoId = 3905171402001 ‘, title:’ Overview of the B and T cell function ‘, description:’ u003Ca id = “v37895536 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eEs are two main classes of lymphocytes that are involved in specific immune functions: B cells and T cells. Immature T cells are produced in the bone marrow

Health Life Media Team

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