Clostridienbedingte Necrotizing Enteritis

(Enteritis necroticans; Pigbel; bowel Brand)

A clostridienbedingte necrotic enteritis is one of Clostridium perfringens. caused necrotizing inflammation of the jejunum and ileum.

A clostridial necrotic enteritis is a mild to severe clostridial infection that can be fatal if not treated immediately.

A clostridienbedingte necrotic enteritis is one of Clostridium perfringens. caused necrotizing inflammation of the jejunum and ileum. A clostridial necrotic enteritis is a mild to severe clostridial infection that can be fatal if not treated immediately. C. perfringens type C can cause occasionally a serious inflammatory disease of the small intestine (especially the jejunum). The disease is caused by Clostridium ?-toxin that is very sensitive to proteolytic enzymes and is inactivated by normal cooking. The inflammation extends segmental and results in smaller or large areas of hemorrhage and necrosis variable proportions. A perforation may occur. Disease occurs mainly in populations with multiple risk factors, including the following: Protein deprivation (caused insufficient synthesis of protease enzymes) Lack of food hygiene Episodic “meat feast” major food with trypsin inhibitors Ascaris infestation (these (e.g., sweet potatoes.) parasites secrete a trypsin inhibitor) These factors are characteristically only in the hinterlands of New Guinea and parts of Africa, Central and South America and Asia collectively present. In Guinea the disease as “Pigbel” is known and is usually transmitted through contaminated pork, other meats and possibly peanuts. The severity varies from mild diarrhea to a fulminant course with severe abdominal pain, vomiting, bloody stools, septic shock and sometimes death h within 24 hours. The diagnosis of clostridial necrotic enteritis is based on the clinical presentation and toxin in the stool. The therapy of a clostridial conditional necrotizing enteritis is carried out with antibiotics (penicillin G, metronidazole). surgical procedures because of a perforation, persistent intestinal obstruction or lack of response to antibiotics are required for about 50% of critically ill patients. An experimental Toxoidvakzine has been successfully used in endemic areas, but is not commercially available. Neutropenic enterocolitis (appendicitis) A similar life-threatening syndrome develops in the cecum of neutropenic patients (z. B. in those with leukemia or anticancer chemotherapy). It can be associated with sepsis due to C. septicum. Symptoms include fever, abdominal pain, gastrointestinal bleeding and diarrhea. The diagnosis of neutropenic enterocolitis based on symptoms, the presence of severe neutropenia and the results of abdominal CT and blood and stool cultures and toxin tests. Typhlitis must be distinguished by the cytomegalovirus C. difficile-induced diarrhea, graft-vs-host disease and colitis. The therapy of Typhlitis done with antibiotics, but surgical measures may also be necessary. Neonatal necrotizing enterocolitis A neonatal necrotizing enterocolitis comes to neonatal intensive care units before and can by C. perfringens, C. butyricum, or C. difficile, caused, but the clarification of a causal role of these pathogens requires further investigation.

Health Life Media Team

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