Chondroitin Sulfate

Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. It is extracted from shark or bovine cartilage or produced synthetically Its composition may vary. and often combined with glucosamine.

(See also nutritional supplements Overview.) Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. It is extracted from shark or bovine cartilage or produced synthetically Its composition may vary. and often combined with glucosamine. Allegations chondroitin sulfate is used in the treatment of osteoarthritis. Scientific evidence shows no benefit when alone chondroitin sulfate is ingested. However, studies suggest that this compound may improve in combination with glucosamine joint pain and joint mobility, and can reduce reduce the dose of conventional anti-inflammatory drugs, if taken over 6-24 months. The effect over longer periods is unknown, the mechanism of action also. Dosage: up to 400 mg 3 times daily 600 mg once daily p.o. Documents Evidence of the efficacy of chondroitin sulfate is investigated contradictory until recently had only small studies chondroitin sulfate alone or in combination with glucosamine to treat osteoarthritis. The Gluck Samin / chondroitin Arthritis Intervention- trial (GAIT), a large, randomized, double-blind, placebo-controlled, multi-center clinical study, the use of glucosamine (500 mg orally three times / day), chondroitin sulfate (400 mg orally three times / day ) as well as the use of both drugs for the treatment of osteoarthritis of the knee zuntersucht; in the group as a whole, the pain was not reduced. However, the exploratory sub-analyzes have demonstrated activity in a subgroup of patients with moderate to severe knee pain out (1). A meta-analysis has also shown that the benefits of chondroitin, if at all, limited (2). It was pointed out that the reason for contradictory symptomatic benefit is the poor quality of a plurality of chondroitin sulfate supplements in food quality, and that chondroitin sulfate in pharmaceutical grade is effective with a defined percent purity and sequences of oligosaccharides and is used for the treatment (3) , Heterogeneous arthritic symptoms and causes also contribute to difficulties in the application in clinical practice. Undesirable effects serious side effects have been reported. The most common side effects include abdominal pain, nausea and other gastrointestinal symptoms. Drug interactions chondroitin sulfate, the anticoagulant action of warfarin (4). Chondroitin sulfate References Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354 (8): 795-808, 2006. Reichenbach S, Sterchi R, Scherer M, et al. Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Ann Intern Med 146 (8): 580-590, 2007. Hochberg M, Chevalier X, Henrotin Y, et al. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what’s the evidence? Curr Med Res Opin 29 (3): 259-267, 2013. Knudsen JF, Sokol GH. Potential glucosamine-warfarin interaction Resulting in Increased international normalized ratio: case report and review of the literature and MedWatch database. Pharmacotherapy 28 (4): 540-548., 2008

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