Chagas Disease

(American trypanosomiasis)

Chagas disease comes about by infection by Trypanosoma cruzi, which is transmitted through bites of assassin bugs (Triatominae). The symptoms start with a skin lesion or a unilateral periorbital edema; are progressing with fever, malaise, generalized lymphadenopathy and hepatosplenomegaly. Years later it comes in some patients chronic cardiomyopathy, megaesophagus or megacolon. The diagnosis is made by the detection of trypanosomes in peripheral blood or aspirates from infected organs. Antibody tests are reliable and can be helpful. Treatment is with nifurtimox or benznidazole.

T. cruzi is transmitted by kissing bugs (Reduviidae, subfamily Triatominae), in particular by about 30 species of the genera Triatoma, Rhodnius, Dipetalogaster and Panstrongylus.

Chagas disease comes about by infection by Trypanosoma cruzi, which is transmitted through bites of assassin bugs (Triatominae). The symptoms start with a skin lesion or a unilateral periorbital edema; are progressing with fever, malaise, generalized lymphadenopathy and hepatosplenomegaly. Years later it comes in some patients chronic cardiomyopathy, megaesophagus or megacolon. The diagnosis is made by the detection of trypanosomes in peripheral blood or aspirates from infected organs. Antibody tests are reliable and can be helpful. Treatment is with nifurtimox or benznidazole. T. cruzi is transmitted by kissing bugs (Reduviidae, subfamily Triatominae), in particular by about 30 species of the genera Triatoma, Rhodnius, Dipetalogaster and Panstrongylus. Pathophysiology While the bite deposit the bug feces on the skin containing metacyclic trypomastigotes. These infectious forms penetrate through the bite wounds or penetrate the conjunctiva or mucous membranes. The parasites infect macrophages at the entry point, transform into amastigotes that multiply by binary division. The amastigotes develop into trypomastigotes, enter the bloodstream and the tissue spaces, where they infect other cells. Most often the cells of the reticuloendothelial system, myocardium, muscles and nervous system are affected. Life cycle of Trypanosoma. Picture of the Centers for Disease Control and Prevention Image Library. var model = {thumbnailUrl: ‘/-/media/manual/professional/images/trypanosoma_life_cycle_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/-/media/manual/professional/images/trypanosoma_life_cycle_high_de.jpg?la = en & thn = 0 ‘, title:’ life cycle of Trypanosoma ‘description:’. u003cdiv class = “list ” u003e u003cul data-mmanualobjecttype = “”list “” class = “”nobulleted “” u003e u003cli u003e u003Ca id = “”v1015889_de “” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003e1. During a blood meal of a predatory bug releases (Triatominae)

Health Life Media Team

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