Trimethoprim And Sulfamethoxazole

Trimethoprim is provided as a single drug or in combination with sulfamethoxazole (a sulfonamide antibiotic sulfonamides) available. The substances synergistically block sequential steps of bacterial folate metabolism. Trimethoprim prevents the reduction of dihydrofolate to tetrahydrofolate. Sulfamethoxazole inhibits the conversion of p -aminobenzoic acid to dihydropteroate. This synergy leads to maximum antibacterial, often bactericidal effect. Trimethoprim / sulfamethoxazole; Trimethoprim-sulfamethoxazole (TMP-SMX) is available as a fixed combination with a mixing ratio of…

September 3, 2018