Tolerance And Resistance

Tolerance is a reduction in drug effect by repeated taking the drug. Resistance is the ability of microorganisms or tumor cells to resist the originally destructive effects of a drug. Examples of drugs (drugs) that lead to tolerance, alcohol and opioids. A responsible for the development of tolerance mechanism is an increased metabolism, for example by induction of liver enzymes such as cytochrome P-450 enzymes (drug metabolism). Other possible mechanisms…

September 3, 2018