Progressive Multifocal Leukoencephalopathy (Pml)

A progressive multifocal leukoencephalopathy (PML) is caused by reactivation of the JC virus. The disease usually occurs in patients with impaired cell-mediated immunity, especially in patients with HIV infection. PML leads to a subacute and progressive demyelination in the CNS and multifocal neurological deficits, it runs, usually within a year, lethal. The diagnosis is made by MRI plus CSF-PCR. In AIDS patients, the highly active antiretroviral therapy can slow the…

September 3, 2018