Primary Myelofibrosis

(Idiopathic myelofibrosis, myelofibrosis, myeloid metaplasia with myelofibrosis) The primary myelofibrosis (PMF) is a chronic, usually idiopathic disease that is characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop erythrocytes. Diagnosis requires a bone marrow examination and can cause a myelofibrosis (secondary myelofibrosis) to the exclusion of other diseases. Treatment is often supportive but JAK2 inhibitors such Ruxolitinib can reduce the symptoms and a stem cell transplant can…

September 3, 2018
Read More >>