The hereditary Kryopyrin-Associated Periodic Syndromes are a group of auto inflammatory conditions that are triggered by cold temperatures. They also include the familiar cold auto-inflammatory syndrome, Muckle-Wells syndrome and the onset in the neonatal period multisystemic auto-inflammatory disease. Hereditary Kryopyrin-associated periodic syndromes represent a wide range of progressive serious diseases. Caused by mutations in the gene encoding the protein cryopyrin which engages in inflammation and in the processing of IL-1?….
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