Hemoglobin E Disease

The homozygous hemoglobin E disease (a hemoglobinopathy; hemoglobinopathies) causes a mild hemolytic anemia, usually without splenomegaly. Hemoglobin E is the world’s third most common (after hemoglobin A and hemoglobin S) hemoglobin variant. It comes mainly in the dark-skinned people and in Southeast Asia (> 15% homozygotes) in the Chinese population, it is rarely seen. Heterozygous (hemoglobin AE) are asymptomatic. Patients with heterozygous hemoglobin E and ?-thalassemia have a more severe…

September 3, 2018