Distribution Of The Drug Into The Tissue

Once a drug has entered the general circulation, it is distributed in the body tissues. The distribution is uneven in general, since differences in the blood flow, tissue binding exist (eg. As a result of the fat content), the local pH and the permeability of the cell membranes. (See also Overview pharmacokinetics.) Once a drug has entered the general circulation, it is distributed in the body tissues. The distribution is…