Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to bacterial cell membranes and caused due to the potassium efflux and the associated destruction of DNA, RNA and protein synthesis rapid depolarization of the membrane which leads to a rapid concentration-dependent bacterial cell death (efficacy). Indications Daptomycin is active against the following: Gram-positive bacteria (broad spectrum) Multi-resistant Gram-positive bacteria (because cross-resistance with other classes…

September 3, 2018