Congenital Adrenal Hyperplasia, Which Is Caused By A Defect Of The 11-Hydroxylase

The 21-hydroxylase deficiency (CYP21A2) gives poor conversion of adrenal hormone precursors to cortisol and in some cases to aldosterone. This sometimes leads to severe hyponatremia and hyperkalemia. Piled hormone precursors are derived in androgen production, resulting in the virilization. The diagnosis is made by the determination of cortisol, its precursors and the adrenal androgens, sometimes after ACTH stimulation. The treatment is performed with glucocorticoids and if necessary a mineralocorticoid. In…

September 3, 2018