Chloramphenicol is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thereby inhibiting protein synthesis. Pharmacology Chloramphenicol is well absorbed after oral administration. Parenteral therapy should be administered intravenously. Chloramphenicol has a large volume of distribution in the body fluids, including cerebrospinal fluid, and is excreted renally. Because of the hepatic metabolism and chloramphenicol does not accumulate in renal failure. Indications Chloramphenicol has a broad spectrum of activity…

September 3, 2018