Bullous Pemphigoid

Bullous pemphigoid The is a chronic autoimmune disease of the skin, resulting in the elderly to generalized itching, bullous lesions. The mucosa is rarely affected. The diagnosis is made by skin biopsy and immunofluorescence tests of skin and serum. First topical and systemic corticosteroids are used. In most patients, is a long-term maintenance therapy, can be used for various immunosuppressants required.

Bullous pemphigoid occurs more frequently in the patients> 60 years, but can also occur in children. IgG autoantibodies bind to specific antigens hemidesmosomal (BPAG1, BPAg2). This complement activation is triggered, which in turn leads to the formation of a subepidermal blister.

Bullous pemphigoid The is a chronic autoimmune disease of the skin, resulting in the elderly to generalized itching, bullous lesions. The mucosa is rarely affected. The diagnosis is made by skin biopsy and immunofluorescence tests of skin and serum. First topical and systemic corticosteroids are used. In most patients, is a long-term maintenance therapy, can be used for various immunosuppressants required. Bullous pemphigoid occurs more frequently in the patients> 60 years, but can also occur in children. IgG autoantibodies bind to specific antigens hemidesmosomal (BPAG1, BPAg2). This complement activation is triggered, which in turn leads to the formation of a subepidermal blister. Etiology this purpose has so far demonstrated no cause. However, the following triggering factors have been proposed: drugs (einschließlichFurosemid, spironolactone, sulfasalazine, penicillin, penicillamine, etanercept and antipsychotics) Physical release (including trauma, radiation therapy for breast cancer, UV radiation and dithranol (anthralin)) skin diseases (including psoriasis, lichen ruber, and some infections) disorders (diabetes mellitus, rheumatoid arthritis, ulcerative colitis and multiple sclerosis) Genetische- and environmental factors may play a role. Triggers can an autoimmune response by mimicking molecule sequences in the epidermal basement membrane (molecular mimicry, as with drugs and possibly infections) induce, through exposure or conversion usually tolerated host antigens (such as physical triggers and certain diseases) or other mechanisms. The spread of epitopes related to the recruitment of autoreactive lymphocytes against normally tolerated host antigens, which contributes to the chronicity of the disease and course. Symptoms and complaints pruritus is the first symptom. Skin lesions may occur only after several years, but often leads to characteristic, tense blisters on normal appearing or erythematous skin of Runpfes and the bendable and intertriginous areas of the body. Localized disease can occur at sites of trauma, the stomata and in anogenital and lower leg areas. Bubbles burst not usually. If they do, they often heal quickly. In addition, polymorphic, Annular dark red, edematous lesions with peripheral bubbles or without can occur. Rarely, small blisters develop on the mucous membrane. Leukocytosis, and eosinophilia are common, but fever is rare. The Nikolsky phenomenon in which to move the upper layers of the epidermis at a slight pressure or rubbing the skin right next to a lateral bladder is negative. Bullous pemphigoid arm © Springer Science + Business Media var model = {thumbnailUrl: ‘/-/media/manual/professional/images/58_bullous_pemphigoid_slide_18_springer_high_de.jpg?la=de&thn=0&mw=350’ imageUrl: ‘/ – / media / manual /professional/images/58_bullous_pemphigoid_slide_18_springer_high_de.jpg?la=de&thn=0 ‘, title:’ Bullous pemphigoid arm ‘description:’ u003Ca id = “v37894558 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDiese figure shows tense bullae

Health Life Media Team

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