Bronchialkarzinoid

Carcinoid of the bronchi are rare, slow-growing neuroendocrine tumors of the bronchial mucosa. They affect patients in the 5th-7th Decade of life.

Half of the patients are asymptomatic and the other half presents with obstructive symptoms including. Dyspnea, wheezing and coughing in front, which often leads to misdiagnosis of asthma. Recurrent pneumonia, hemoptysis and chest pain also occur often.

Carcinoid of the bronchi are rare, slow-growing neuroendocrine tumors of the bronchial mucosa. They affect patients in the 5th-7th Decade of life. Half of the patients are asymptomatic and the other half presents with obstructive symptoms including. Dyspnea, wheezing and coughing in front, which often leads to misdiagnosis of asthma. Recurrent pneumonia, hemoptysis and chest pain also occur often. Paraneoplastic syndromes, including Cushing’s syndrome due to ectopic ACTH production, acromegaly by ectopic GRF (growth hormone releasing factor) – production and Zollinger-Ellison syndrome due to ectopic gastrin production are more common than a carcinoid syndrome, which in <3% of patients occurs with carcinoid. A left sided heart murmur (mitral stenosis or insufficiency) with a serotonin-induced valve damage rarely occurs with bronchial Karcionoiden on (as opposed to the right heart valve damage in GI carcinoids). Diagnosis Bronchoscopic biopsy The diagnosis is based on a bronchoscopic biopsy obtained, but the evaluation often initially includes a chest CT, with up to one third of the patients tumor calcifications are seen on the. In order to determine a local or metastatic expansion scintigraphy with Indium-111-labeled octreotide is useful. Increased serotonin and 5-HIAA levels support the diagnosis, but the levels of these substances are not often increased. Therapy Surgical procedures Treatment consists of surgical removal with or without adjuvant chemotherapy and / or radiation therapy. The prognosis depends on the type of tumor. The 5-year survival in well-differentiated carcinoid is> 90%, in atypical tumors they liegte at 50-70%.

Health Life Media Team

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