Autonomic Neuropathies

Autonomic neuropathies are diseases of the peripheral nerves with predominant involvement of autonomous fibers.

The best-known autonomic neuropathies occur concomitantly to diabetic peripheral neuropathy, amyloidosis or autoimmune diseases.

Autonomic neuropathies are diseases of the peripheral nerves with predominant involvement of autonomous fibers. The best-known autonomic neuropathies occur concomitantly to diabetic peripheral neuropathy, amyloidosis or autoimmune diseases. The autoimmune autonomic neuropathy is an idiopathic disorder that often develops after a viral infection; its onset may be subacute. Autonomous insufficiency is usually a late manifestation of alcoholic neuropathy. Other causes may be toxins, drugs, and paraneoplastic syndromes. Symptoms and complaints Common symptoms include autonomic neuropathy, orthostatic hypotension, neurogenic bladder dysfunction, erectile dysfunction, gastroparesis and persistent constipation. If somatic fibers are involved, sensory loss with a sock and glove-shaped distribution pattern and distal weakness can occur (overview of disorders of the peripheral nervous system). Diagnosis Clinical evaluation The diagnosis of an autonomic neuropathy is based on the occurrence of autonomic failure and a specific cause of the neuropathy (eg. As diabetes mellitus, amyloidosis). An autoimmune autonomic neuropathy may be suspected after a viral infection. The ganglionic anti-acetylcholine receptor antibody A3 occurs in patients with other autonomic neuropathies in about half of patients with autoimmune autonomic neuropathy and, occasionally. Treatment Treatment of underlying medical disorders The underlying be treated causally. An autoimmune autonomic neuropathy may be responsive to immunotherapy; plasmapheresis or i.v. administration of ?-globulin can be used in severe cases.

Health Life Media Team

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