Anabolic Steroids

Among the anabolic steroids include testosterone and substances that are chemically or pharmacologically related to testosterone, which promotes muscle growth; there are a large number of specimens in trade. Anabolic steroids are used clinically to treat low testosterone levels in male hypogonadism (hypogonadism in men. Because anabolic steroids are anti-catabolic and improve protein utilization, administered to patients with severe burns, bed-ridden or otherwise debilitated patients to prevent muscle breakdown.

Anabolic steroids are often used for improving physical performance and muscle growth. For permanent high-dose use without medical supervision can lead to mood swings and irrational behavior and various physical side effects. Among the anabolic steroids include testosterone and substances that are chemically or pharmacologically related to testosterone, which promotes muscle growth; there are a large number of specimens in trade. Anabolic steroids are used clinically to treat low testosterone levels in male hypogonadism (hypogonadism in men. Because anabolic steroids are anti-catabolic and improve protein utilization, administered to patients with severe burns, bed-ridden or otherwise debilitated patients to prevent muscle breakdown. Enact Some doctors . also patients with AIDS-related muscle loss and cancer patients anabolic steroids However, there are few data supporting the efficacy of such therapy, and little guidance on the influence of the underlying diseases by androgen supplements testosterone to promote wound healing and help with muscle injuries. but there is no data to support these theories Anabolic steroids are used illegally to increase muscle mass and strength;. weight training and a special diet can increase these effects There is no direct evidence for the Improvement. ung of endurance or speed through anabolic steroids, but anecdotal reports suggest that athletes who use anabolic steroids can often train with high intensity. The muscular hypertrophy is unique. According to estimates the lifetime incidence of Anabolikamissbrauchs is 0.5-5% of the population, with significant differences in subpopulations (eg. As higher rates in bodybuilders and competitive athletes). According to reports, anabolic steroids in the United States of about 6-11% of male adolescents in high school age are, incl. an unexpectedly high number of non-athletes, and about 2.5% of female adolescents used. Pathophysiology They act androgen (changes in hair growth or libido, aggressiveness) and anabolic (increased protein synthesis, building muscle mass). Androgenic and anabolic effects can not be separated. To minimize the androgenic effects, but some anabolic steroids were synthesized. Testosterone is rapidly metabolized in the liver; orally administered testosterone is inactivated too fast to be effective and for injection given testosterone modified (eg., by esterification) is to delay absorption and degradation. modified by 17-alpha alkylation analogues are often effective orally, but have stronger side effects. There are also transdermal preparations available. Chronic effects The respective side effects are highly dose- and substance-dependent. The side effects are physiological doses at low (eg., Methyl testosterone 10-50 mg / day or equivalent). Athletes can take up to 10 to 50 times this dose. At high doses, some side effects are clearly documented, but others are doubtful (s. Side effects of anabolic steroids). Uncertainties arise from the fact that most studies were also conducted with subjects who abuse these substances and therefore does not necessarily indicate the doses correctly. Often anabolic steroids are also used on the black market acquired, many of which are fake and contain various dosages and substances that are not properly specified in the product information. Side effects of anabolic steroids clearly shown erythrocytosis abnormal lipid profile (decreased HDL, increased LDL) liver abnormalities: peliosis hepatitis, adenoma Mental disorders (with high doses) androgens effects: acne, hair loss, virilization and hirsutism in women Gonadal suppression (reduced sperm count, testicular atrophy) gynecomastia Premature closure of the epiphyseal questionable hypertension and LVH deterioration of prostatic carcinoma or preexisting liver cancer Poor shown * Increased risk of sudden death in athletes Significant affective disorder at low doses * Predominantly with 17-alpha-alkylated analogues. HDL = high-density lipoprotein, LDL = low-density lipoprotein; LVH = left ventricular hypertrophy. Athletes take steroids often over a certain period, then putting it off, and start again with the taking; this cycle repeat several times a year (Cycling). It is believed to normal in these temporary taking breaks endogenous testosterone levels, sperm count, and the hypothalamic-pituitary-gonadal axis again. Anecdotally, the cyclical application reduces adverse effects, and reduces the need for higher and higher doses to achieve the desired effect. Athletes often use many drugs simultaneously ( “stacking”) and apply it in different ways (oral, i.m., or transdermal). Dose escalation during one cycle ( “pyramiding”) can lead to doses that are higher by 5 to 100 times than the physiological dosage. receptor bonds are enhanced by stacking and pyramiding and side effects are minimized; this there is so far no evidence, however. Symptoms and signs The most characteristic sign is a rapid increase in muscle mass. How fast and how intensively this muscle building proceeds, is directly dependent on the ingested Anabolikadosis. People taking physiological doses, there will be a slow and often barely noticeable growth; among people taking megadoses, the lean muscle mass can increase by several pounds per month. Energy levels and libido (in men) can increase also; However, these effects are difficult to identify. Psychological effects (generally only at very high doses) are often noticed by family members: Widely different and erratic mood swings irrational behavior Increased aggressiveness irritability Increased libido Depression Increased acne is common among both sexes; libido may increase or, less commonly, decrease; Aggressiveness and appetite may increase. Gynecomastia, testicular atrophy and reduced fertility can occur in men. Some of which occur in women virilizing effects may be irreversible (eg. As alopecia, enlargement of the clitoris, hirsutism, deepening of the voice). Also, the breast size may decrease; is vaginal atrophy and menstruation may change or stop. Virilization and gynecomastia may be irreversible. Diagnostic Urinalysis The Anabolikagebrauch can be detected with a urine test normally. The metabolites of anabolic steroids can be detected (some Anabolikatypen even longer) up to 6 months after discontinuation of substances. Testosterone eigenommen exogenous, is indistinguishable from endogenous testosterone. If, however, high levels of testosterone are detected, the relationship between testosterone and epitestosterone (an endogenous steroid which is chemically almost identical to testosterone) is measured. Normally, the ratio <6:01; when exogenous testosterone is used, the ratio is higher. Treatment discontinuation of substance The main treatment consists in stopping the substance. Although physical dependence does not occur, there may be a psychological dependence, particularly in competitive bodybuilders. Gynecomastia may require surgical reduction. Prevention especially in adolescents and young adults should make doctors aware of signs of Anabolikamissbrauchs and inform patients about the risks. Education about anabolic steroids should start from the age of 10 years. promote the use of programs that alternative, healthy ways to increase muscle mass and improve performance through good nutrition and special strength training techniques that can help. Both the risks and the benefits of use of anabolic steroids show seems to be a more effective way to educate young people about the negative effects of the use of illegal steroids.

Health Life Media Team

Leave a Reply