Adenomatous Polyposis Family

Familial adenomatous polyposis (FAP) is an inherited disease which causes innumerable colonic polyps and to the age of 40 results in a colon carcinoma. Patients are usually asymptomatic, but may have Haemoccult®-positive stools. Diagnosis is made by colonoscopy and a genetic test. Treatment consists of colectomy.

FAP is an autosomal dominant disease in which ? 100 adenomatous polyps the colon and rectum lining. The incidence is 1: 8000 to 1: 14,000. Up to 15 years polyps are present in 50% of patients up to 35 years at 95%. In almost all untreated patients, cancer developed until age 40.

Familial adenomatous polyposis (FAP) is an inherited disease which causes innumerable colonic polyps and to the age of 40 results in a colon carcinoma. Patients are usually asymptomatic, but may have Haemoccult®-positive stools. Diagnosis is made by colonoscopy and a genetic test. Treatment consists of colectomy. FAP is an autosomal dominant disease in which ? 100 adenomatous polyps the colon and rectum lining. The incidence is 1: 8000 to 1: 14,000. Up to 15 years polyps are present in 50% of patients up to 35 years at 95%. In almost all untreated patients, cancer developed until age 40. Patients can also use the various manifestations outside of the colon develop (formerly known as Gardner’s syndrome called), both benign and malignant. Benign manifestations include desmoid tumors, osteomas of the skull or lower jaw, atheromas (cheesefeet) and adenomas in other parts of the gastrointestinal tract. The patients have an increased risk of cancer in the duodenum (5-11%), pancreas (2%), thyroid (2%), brain (medulloblastoma in <1%) and liver (hepatoblastoma at 0.7% of children <5 years) , Symptoms and complaints Many patients are asymptomatic, but it occurred rectal, typically occult bleeding on. Diagnostic colonoscopy Genetic testing of patients and 1st degree descendants are to hepatoblastoma screened Diagnosis is at> 100 colonoscopy found polyps. Diagnosed patients should get a genetic test to identify the specific mutation, this should then be sought in first-degree relatives. If a genetic test can be carried out, relatives of the patients from the age of 12 should be sigmoidoskopiert annually, with each decade, the interval may be extended. If by the age of 50. No polyps were found, the same screening recommendations as for patients at average risk apply. Adenomatous polyposis CNRI family / SCIENCE PHOTO LIBRARY var model = {thumbnailUrl: ‘/-/media/manual/professional/images/m2400425-familial-adenomatous-polyposis-science-photo-library-high_de.jpg?la=de&thn=0&mw= 350 ‘, imageUrl’ /-/media/manual/professional/images/m2400425-familial-adenomatous-polyposis-science-photo-library-high_de.jpg?la=de&thn=0 ‘, title:’ Familial adenomatous polyposis’ description: ‘ u003Ca id = “v37892584 ” class = “”anchor “” u003e u003c / a u003e u003cdiv class = “”para “” u003e u003cp u003eDieses photo shows a colectomy specimen with numerous polyps in the colon u003c / p u003e u003c / div u003e ‘credits’. CNRI / SCIENCE PHOTO LIBRARY’

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