The breast is consist of glands called lobules that produce milk, and the milk is carried through thin tubes called ducts that extend from the lobules, reaching the nipple. The breast also contains fat, connective tissue, lymph nodes and blood vessels.
The most well-known type of breast cancer is ductal carcinoma. This form of cancer starts in the cells of the ducts. Although it can also begin in lobules cells and other tissues of the breast. Invasive breast cancer is a type that begins in a particular part, such as the ducts or lobules and then spreads to the surrounding tissue.
In the United States, breast cancer is the most common type cancer for women, after the skin cancer, which is the # 1 type of cancer. Breast cancer occurs in men and women. However, it is very rare for men to develop breast cancer. Each year nearly 230,000 women are diagnosed with new cases of cancer while only 2,300 or at 1% of the diagnoses are in men. Even though men breast cancer is not common, it sill must be taken very seriously. There are more than 3,000,000 reported cancers of breast cancer in the US.
In many cases, the first sign of breast cancer is a lump within the breast, there can also be an abnormal reading in a mammogram test. There are several different stages of breast cancer, from early, curable stage of cancer to metastatic breast cancer. There are variety of different breast cancer treatments.
Although the specific cause of breast cancer is not very clear, we know that there are main risk factors that determine the likelihood of someone getting breast cancer. However, most women who are considered high risk for developing breast cancer do get, and many women who have no known risk develop breast cancer. The most significant factor fo developing breast cancer is age and family, the genetic history of breast cancer. There is also increased the risk for women who have benign breast lumps. Also women, who have previously had ovarian cancer are at higher risk.
Women whose mother, sister or daughter, has had breast cancer is two to three more times more likely to develop cancer. This risk is particularly pertinent if more than one first-degree family relative has been affected by breast cancer.
Medical researchers have distinguished tow genes in particular, responsible for some instances of genetic breast cancer. These genes identified as BRCA1 and BRCA2. Around one and two hundred carry these genes. Although having them predispose women to develop breast cancer, it does not ensure that she develops it in the future.
Women over the age of 50 are also more likely get breast cancer than younger women. Women of African-American are more likely to do that than Caucasians to get breast cancer before menopause.
There is also a link between hormones an breast cancer. Researchers now believe that women with higher exposure to the hormone estrogen are more susceptible to breast cancer. The estrogen hormone causes cells to divide, and the more cell the division, the higher the likeliness of an abnormal cell becoming cancerous.
A women’s exposure to progesterone as estrogen changes throughout her lifetime, rising and falling. Her age influences these levels, menstruation, the average length of her menstrual cycle and her age during her first childbirth. The risk of breast cancer she starts to menstruation before the age 12, have her first child after the age of 30, stops menstruation after age 55 or have menstruation cycles that are shorter or exceeds 26-29 days. Current data shows that birth control pill hormones likely do not have substantively increase risk. There are some studies that show taking hormone replaced therapy after menopause has cured, may increase the risk of breast cancer, particularly if the therapy is taken longer than five years. This data is still inconclusive. Heavy doses of radiation therapy may be a large factor, low-dose from mammograms should not pose any risk.
In Men, the causes of breast cancer are DNA-based as well. Gene mutations occur during life rather than being passed down through genetic inheirtance. It is not clear what causes these genetic mutations. Some acquired mutations of oncogenes or tumor suppressor genes may result in cancer-causing chemicals in the environment or diet.
For men, the risk factors increase with age as well. The average age of diagnosis is 68 years old. One out of five men with breast cancer is a close relative of someone with breast cancer.
Det finns några studier som har hittat en anslutning till män med Klinefelters syndrom som drabbar omkring 1 in 1,000 män. Klinefelters syndrom är ett medfött tillstånd (vid födseln) som förändrar X och Y kromosomkomposition. Män är normalt föds med en X-kromosom och Y-kromosom. Kvinnor föds med 2 X-kromosomer. Män med Klinefelters syndrom har en Y-kromosom plus, minst, två X-kromosomer.
Östrogenbehandling som en gång användes av män med prostatacancer kan öka riskfaktorn. Transgender/transsexual people, who take high doses of estrogen, in sex reassignment can develop the higher risk of breast cancer.
There have also been studies on the link between diet and breast cancer. Although lifestyle choices, such as eating obesity are causing foods, drinking alcohol regularly and smoking may promote the disease. Diets that are high in fat content are more likely to develop breast cancer. Lowering a diet that calories from fat is less than 20-39% may help protect her from developing breast cancer.