Qu'est-ce que Actinic Cheilitis (AC)?


Quel est Actinic cheilitis
Actinic cheilitis manifests a diffuse or patchy dryness and variable thickening of the vermillion of the lower lip. La forme la plus courante de chéilite actinique est due à une exposition chronique au soleil. Il est aussi appelé chéilite actinique, chéilite solaire et parfois, chéilite actinique avec atypies histologique.
AC affecte presque toujours les lèvres inférieures et que rarement la lèvre supérieure, probably because of the lower lip more exposed to the sun. In the unusual cases reported where it affects the upper lip, this may be due to upper lip prominent commissures (coins de la bouche ne sont généralement pas impliqués.
Les personnes atteintes peuvent éprouver des symptômes tels que sensation de sécheresse et à la fissuration des lèvres. Il est généralement indolore et persistante.
L'aspect est variable. lésion blanche indique rouge hyperkératose, lésions érosives ou ulcéreuses indiquent la perte de l'épithélium et l'inflammation. De bonne heure, la lésion aiguë peut être érythémateuse (rouge) et oedémateux (gonflé) mois et des années d'exposition au soleil, la leçon devient chronique et peut être gris-blanc et apparaissent à sec, squameuse et ridée.

Pourquoi dois-je avoir des lèvres sèches et gercées?

Il est la pensée, une coloration blanchâtre de la lèvre à la frontière de la lèvre et de la peau. Il épaissit Tache blanchâtre de la lèvre au bord de la bouche et de la peau. Il y a aussi une baisse de la frontière habituellement nette entre le rouge de la lèvre et lui peau normale, connu sous le nom de la frontière vermillon. Cela peut devenir squameuse et durci comme AC continue.

Lorsque l'on frotte la main contre la lèvre, vous remarquerez peut-être la lèvre ont une texture semblable à frotter le doigt ganté le long du papier de verre.

AC may occur with skin lesions of actinic keratosis or skin cancer else particularly on the head he neck since these are the most sun-exposed areas. Rarely it may represent a genetic susceptibility to light damage (par exemple, xeroderma pigmentosum or actinic prurigo).

Causes
AC is created by chronic and excessive exposure to ultraviolet radiation in sunlight Risk factors include:

Outdoor lifestyle: par exemple, farmers, fishers, windsurfers, mountaineers, golfers. This has given rise to synonyms for this condition such as sailor’s lip and farmer’s lip. There is a prevalence of agricultural workers in a semi-arid region of Brazil who report AC in some areas as high as 16.7%
Light skin complexion: the condition typically affects people with lighter skin tones. Partially Caucasian living in tropical regions. IN one report, 96% or person with AC had phenotype 11 according to the Fitzpatrick scale.
Age: AC commonly affects older individuals, and rarely those under 45 ans.
Le genre. The condition affects males more commonly than females; Sometimes this ratio is reported as high as 10:1

Actinic cheilitis also describes lip improvement in actinic prurigo, a rare form of photosensitivity.

Who gets actinic cheilitis
Actinic cheilitis largely influences adults with fair skin who live in tropical or subtropical areas, especially outdoors workes. They frequently recall having sunburned lips in earlier years. They may also have actinic keratoses on other sun-exposed sites of the scalp, ears, visage, et les mains.
Actinic cheilitis is three times more in males than in females.
What causes actinic cheilitis?
Actinic cheilitis results from chronic exposure of the lower lip to solar ultraviolet radiation It is more vulnerable than encompassing skin because mucosal epithelium is thinner and less pigmented than the epidermis.
What are the clinical symptoms of actinic cheilitis?
Actinic cheilitis most commonly affects the lower lip (90%), and causes:

  1. Skin Dryness
  2. Thinned fragile skin
  3. épaissi, scaly papules and plaques (actinic keratoses)
  4. Less common symptoms of actinic cheilitis include;
  5. Rougeur
  6. Soreness
  7. Gonflement
  8. Fissuring, focal ulceration, and cutting
  9. White thickened patches (leukokeratosis)
  10. Loss of demarcation/Marks and lipline between the vermillion border of the lip and its adjoining skin
  11. Discoloured skin with pale or yellow area
  12. IIf applying lipstick, which tends tobleed into the surrounding lines
  13. Prominent folds and lip lines.

What is the complication of actinic cheilitis?
Actinic cheilitis is a pre-malignant condition. It predisposes to:

Intraepidermal carinoma (Bowen disease or squamoous cell carinoma in situ) .
Invasive squamous cell carcinoma
Cancer of the lip is more in smokers than in non-smokers. Other factors involve oncogenic human papillomavirus (wart virus), immunosuppression and alcohol abuse.

Invasive squamous cell carcinoma should be suspected if the lip is focally tender, or a persistent ulcer or enlarging nodule develops.

How is actinic cheilitis diagnosed?
Actinic cheilitis is generally diagnosed clinically; a skin biopsy may require fluorouracil if skin cancer or an inflammatory cause of cheilitis is presumed.

The pathological characteristics of actinic cheilitis are mutable thickening or atrophy of the lip, partial thickness epidermal dysplasia, solar elastosis and inflammation in the dermis of the skin.

What is the therapy and treatment options for actinic cheilitis?
Smoking for an extended period, and lifelong, year-round, daily sun protection are essential.
Limit sun exposure
Wear a hat with a wide brim
Appliquer un baume à lèvres contenant un écran solaire fréquemment

Les hommes peuvent envisager de cultiver une moustache.
Les thérapies topiques pour chéilite actinique sont non approuvées. Ils comprennent:

La thérapie photodynamique thérapie -Photodynamic (PDT) est un traitement qui utilise un médicament, fait référence à un photosensibilisateur ou un agent photosensibilisant, et un type de lumière distincte. Lorsque photosensibilisateurs sont révélés à une longueur d'onde spécifique de la lumière, ils produisent une forme d'oxygène qui tue les cellules voisines.

Chaque photosensibilisant est activé par une lumière d'une longueur d'onde spécifique. This wavelength defines how far the light can travel into the body. Ainsi, physicians use specific photosensitizers and wavelengths of light to treat different areas of the body with PDT.

Imiquimod cream (Aldara) is an immune response modifier that has been analyzed for the treatment of actinic cheilitis. It develops an immune response in the skin leading to apoptosis (décès) or the tumor cells. It produces the epidermis to be invaded by macrophages, which leads to epidermal erosion. T-cells are also stimulated as a consequence of imiquimod treatment. Imiquimod seems to promote an “immune memory” that decreases the recurrence of lesions; There is minimal scarring. Complete clearance has been shown in up to 45% of patients with actinic keratoses. However, the dose and duration of therapy as well as the long-term efficacy, still need to be established for the treatment of actinic cheilitis.

5-fluorouracil cream – Topical 5-fluorotic (5-FU, Efudex, Carac) has been shown to be an efficient therapy for diffuse, but minor actinic cheilitis, 5-fluorouracil works by blocking DNA synthesis. Cells that are quickly growing require additional DNA, so they accumulate more 5-fluorouracil, ending in their death. Healthy skin is much less affected. The treatment normally takes 2-4 weeks based on the response. The expected response includes a swelling phase, followed by redness, oozing, brûlant, and finally erosion. Treatment is discontinued when ulceration and crusting develop. There is minimum scarring Complete clearance has been reported in about 50% des patients.
Les rétinoïdes topiques

Physical call treatment for actinic cheilitis include:

  • cryothérapie
  • Électrocautère
  • Laser ablation, par exemple, with Er: YAG laser
  • Vermilionectomy (Surgical removal of the external lip)

How can actinic cheilitis be prevented?
Actinic cheilitis can be avoided by protecting the lips from sun exposure. IN smokers, the risk of cancer can be reduced by smoking cessation.